Bodies that Speak

Inclusion bodies: not that bad…

The formation of inclusion bodies (IBs) constitute a frequent event during the production of heterologous proteins in bacterial hosts. Although the mechanisms leading to their formation are not completely understood, empirical data have been exploited trying to predict the aggregation propensity of specific proteins while a great number of strategies have been developed to avoid the generation ...

INVESTIGATION OF REASONS THAT IMPLY THE DIMINISHED INCLUSION BODIES IN E. COLI

Bubble speak

almost impossible even to ask many of these questions clearly without understanding statistics and computational approaches. And these problems require ever-sharper experimental tools, many of which will come from exploiting highly specific chemical reactions and interactions. What are the main challenges you see for the biomedical science community? We are tackling more genomes, ever more prot...

Silent Synapses Speak Up

*Department of Psychiatry The existence of silent or ineffective synapses in the †Department of Cellular and Molecular spinal cordwas proposed over 20 years ago (Wall, 1977), Pharmacology based on experimentally induced rapid changes in the Department of Physiology ability of afferents to evoke single unit activity. However, University of California a limitation of this approach was that it was...

Do you speak chemistry?

I n his famous fantasy epic, The Lord of the Rings, British writer and Professor of English Language and Literature, J. R. R. Tolkien, invented the Ents: tree-like creatures who were some of the oldest beings in his fantasy world of Middle-earth. In Tolkien’s story, the Ents used a unique and ancient language to communicate with each other in a very deliberate way. Tolkien described this langua...